Practice: an upper urinary tract cancer in a dyer. European Journal of Cancer 2006; 42(10):1448–1454.  |  Methods. Close × Term Options.  |  Aniline damages hemoglobin, a protein that normally transports oxygen in the blood. The union requested this investigation because eight cases of bladder cancer had been reported between 1973 and 1988 among workers in the department where there was a potential for exposure to o-toluidine and aniline. Meanings of "aniline cancer" in German English Dictionary : 2 result(s) Kategorie Englisch Deutsch; Work Safety: 1: Work Safety: aniline cancer: Anilinkrebs [m] 2: Work Safety: aniline cancer : Aminotumor [m] × Pronunciation in context (out of ) Pronunciation of aniline cancer. Complementary & Alternative Medicine (CAM), Coping with Your Feelings During Advanced Cancer, Emotional Support for Young People with Cancer, Young People Facing End-of-Life Care Decisions, Late Effects of Childhood Cancer Treatment, Tech Transfer & Small Business Partnerships, Frederick National Laboratory for Cancer Research, Milestones in Cancer Research and Discovery, Step 1: Application Development & Submission, chronic lymphocytic leukemia/small lymphocytic lymphoma, http://www.fda.gov/aboutfda/centersoffices/officeoffoods/cfsan/default.htm, http://monographs.iarc.fr/ENG/Monographs/vol99/index.php, U.S. Food and Drug Administration page: Hair Dyes, U.S. Department of Health and Human Services. Conclusion: The pooled analysis included 4,461 women with NHL and 5,799 women who did not have NHL. American Journal of Epidemiology 2006; 164(1):47–55. In 1834, Friedlieb Runge isolated a substance from coal tar that turned a beautiful blue color when treated with chloride of lime. This kind of leather is also easier to clean. Human cancer data are insufficient to conclude that aniline is a cause of bladder tumors while animal studies indicate that aniline causes tumors of the spleen. Aniline dyes were some of the first synthetic dyes and at the time were very popular because they were much more colorfast than the older natural dyes. Mendelsohn JB, Li QZ, Ji BT, et al. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. It is not known whether some of the chemicals still used in hair dyes can cause cancer. Koutros S, Silverman DT, Baris D, et al. doi:10.1002/ijc.1547. Before his discovery, purple … USA.gov. Risk for lung cancer in workers exposed to benzidine and/or beta-naphthylamine: a protocol for systematic review and meta-analysis. Richardson BG, Jain AD, Potteti HR, Lazzara PR, David BP, Tamatam CR, Choma E, Skowron K, Dye K, Siddiqui Z, Wang YT, Krunic A, Reddy SP, Moore TW. Permanent hair dyes, which make up about 80% of currently marketed products, consist of colorless dye “intermediates” (chemicals called aromatic amines) and dye “couplers.” In the presence of hydrogen peroxide, the intermediates and couplers react with one another to form pigment molecules. He named it kyanol or cyanol. A number of studies have investigated the relationship between the personal use of hair dyes and the risk of NHL, with conflicting results. Aniline Revision Date 07-Dec-2018 Hazard Statements Combustible liquid Toxic if swallowed Toxic in contact with skin May cause an allergic skin reaction Causes serious eye damage Toxic if inhaled May cause drowsiness or dizziness Suspected of causing genetic defects Suspected of causing cancer Causes damage to organs through prolonged or repeated exposure Precautionary Statements … Studies of the association between personal hair dye use and the risk of leukemia have had conflicting results. [8] The IARC lists it in Group 3 (not classifiable as to its carcinogenicity to humans) due to the limited and contradictory data available. Kogevinas M, Fernandez F, Garcia-Closas M, et al. Takkouche B, Etminan M, Montes-Martinez A. Hair dye use and risk of adult acute leukemia. Appearance. cancer usually of the urinary bladder, occurring among those who work with aniline dyes; called also dye workers' c.. Medical dictionary. The aniline dye, mixed with oils, soaks into the leather, giving it added softness and a rich look. Modern hair dyes are classified as permanent (or oxidative), semipermanent, and temporary. Men experienced elevated total cancer mortality (standardized mortality ratio [SMR] = 125; 95% CI: 110-142) and urinary bladder cancer mortality (SMR = 279; 95% CI: 192-391), and increased all malignancy (standardized incidence ratio [SIR] = 142; 95% CI: 125-160), oesophageal (SIR = 203; 95% CI: 108-347), respiratory tract (SIR = 154; 95% CI: 120-194) and bladder (SIR = 394; 95% CI: 268-559) cancer incidence. Cancer morbidity in those directly exposed to betanaphthylamine and benzidine was 1.8 and 2 times the expected one for males and females, respectively (p less than 0.05). Where, bita-napthol = napthelene +alcohols. 2; H351 Suspected of causing cancer . Because the small size of some studies may have limited their ability to detect an association between hair dye use and cancer, a pooled (combined) analysis of four case-control studies was carried out (8). Cancer incidence and mortality statistics worldwide and by region Incidence Mortality Both sexes Males Females Both sexes Males Females New cases Cum. Tomioka K, Saeki K, Obayashi K, Tanaka Y, Kurumatani N. Syst Rev. The high risk of bladder cancer observed originally in workers in the aniline dye industry was probably due to exposure to chemicals other than aniline. Epub 2018 Aug 31. Methods: A historical cohort was assembled and followed-up from 1 January 1975 to 31 December 1989. Anilin (nach spanisch oder auch arabisch: an-nil = blau = Indigo-Farbe) oder Benzenamin ist eine klare, farblose bis schwach gelbliche, ölige Flüssigkeit mit eigenartigem Geruch, die an der Luft schnell rötlich-braun wird. Die basische Wirkung von Anilin wird durch den mesomeren Effekt abgeschwächt, da dieser die Elektronendichte der Aminogruppe verringert. Acute Tox. A report from the International Agency for Research on Cancer (IARC) concluded that some of the chemicals these workers are exposed to occupationally are “probably carcinogenic to humans” (7). Muta. This condition is known as methemoglobinemia and its severity depends on how much you are exposed to and for how long. Clin B; "RecoCancerProf" Working Group, Pairon JC. International Journal of Cancer 2001; 91(4):575–579. HHS Researchers who reviewed data from 14 studies of female breast cancer and hair dye use published between 1977 and 2002 found that dye users had no increase in the risk of breast cancer compared with nonusers (5). Hartge R, Hoover R, Altman DF, et al. Because so many people use hair dyes, scientists have tried to determine whether exposure to the chemicals in hair coloring products is associated with an increased risk of cancer in people. The semi-aniline process adds a thin protective coat to the leather which protects it from wear and stains. Critical Reviews in Toxicology 2007; 37(6):521–536. An analysis of data pooled from 17 studies of personal hair dye use found no evidence of an increased risk of bladder cancer (11). 1996 Feb;25(1):226-7. doi: 10.1093/ije/25.1.226-a. Turati F, Pelucchi C, Galeone C, Decarli A, La Vecchia C. Personal hair dye use and bladder cancer: a meta-analysis. Hair dye use is not associated with risk for bladder cancer: evidence from a case-control study in Spain. Studies of individuals exposed to aniline but to no other known bladder carcinogens have shown little evidence of increased risk. This was an aniline dye derivative into which arsenic had been incorporated. Cancer incidence and mortality were evaluated among 4581 aniline dye production workers in Moscow. No risk increases were seen among users of more recent dye formulations. The results of the study showed that women who began using hair dye before 1980 had a slightly (30%) increased risk of NHL compared with women who had never used hair dye, whereas no such increase in risk was seen for women who began using hair dye after 1980. Unfortunately, aniline dyes were found to be fairly potent carcinogens. When aniline is react with benzene diazonium chloride then it gives azo dyes. Use of hair dyes and risk of bladder cancer. If you smoke for many years, these chemicals pass into your bloodstream and are filtered by the kidneys into your urine. English Spanish online dictionary Tureng, translate words and terms with different pronunciation options. Andrew AS, Schned AR, Heaney JA, Karagas MR. Bladder cancer risk and personal hair dye use. Replacement of a Naphthalene Scaffold in Kelch-like ECH-Associated Protein 1 (KEAP1)/Nuclear Factor (Erythroid-derived 2)-like 2 (NRF2) Inhibitors. Given the widespread use of hair dye products, even a small increase in risk may have a considerable public health impact (3). Mit Flexionstabellen der verschiedenen Fälle und Zeiten Aussprache und … Close. Personal use of hair dyes and risk of cancer: a meta-analysis. Personal use of hair dye and cancer risk in a prospective cohort of Chinese women. In December 1989, NIOSH completed a study of bladder cancer incidence at a plant that had used o-toluidine and aniline since 1957 to manufacture a rubber antioxidant [NIOSH 1989]. 2020 Sep 1;32:e31. Lin J, Dinney CP, Grossman HB, Wu X. Aniline is toxic by inhalation of the vapour. A historical cohort was assembled and followed-up from 1 January 1975 to 31 December 1989. Clipboard, Search History, and several other advanced features are temporarily unavailable. The excess of bladder cancer deaths observed in clusters of cases of workers in the aniline-dye industry has been attributed to exposure to chemicals other than aniline. Studies of breast and bladder cancer have also produced conflicting results. This site needs JavaScript to work properly. In 1842, Nikolay Nikolaevich Zinin reduced nitrobenzeneand … Der systematische IUPAC-N… Results: Bladder cancer is the ninth most common cancer worldwide, with 429 793 incident cases and 165 068 deaths estimated to have occurred in 2012. Aniline was first isolated in 1826 by Otto Unverdorben by destructive distillation of indigo. risk 0-74 (%) Deaths Cum. Women had elevated oesophageal (SMR = 313; 95% CI: 124-664) and bladder (SMR = 311; 95% CI: 149-571) cancer mortality and elevated all malignancy (SIR = 124; 95% CI: 106-144), oesophageal (SIR = 348; 95% CI: 140-719), and bladder (SIR = 861; 95% CI: 458-8002) cancer incidence. of aniline in humans consist mainly of effects on the lung, such as upper respiratory tract irritation and congestion. The International Agency for Research on Cancer (IARC) determined that aniline is not classifiable as to its carcinogenicity to humans. Although these results are consistent with the idea that earlier hair dyes were more carcinogenic, it is also possible that the absence of increased risks for hair dye users who began using dyes after 1980 reflects lower cumulative exposure levels or insufficient time since first exposure for any increase in risk to become apparent. How can aniline affect children? Volume 99: Some Aromatic Amines, Organic Dyes, and Related Exposures. International Journal of Cancer 2001; 94(6):903–906. Smoking is the single biggest risk factor for bladder cancer. SAFETY DATA SHEET ANILINE Version 6.0 – 01.02.2018 2 / 14 Eye Dam. Similarly; 3. In the 1950s, at Cincinnati Chemical Works, almost half of the long-term workers who handled a dye compound called benzidine got bladder cancer. Moscow district oncologic dispensary registries furnished case ascertainment and employer records provided job exposure data. What is the evidence that personal hair dye use is associated with risk of NHL? Methemoglobinemia is the most prominent symptom of aniline poisoning in … Gago-Dominguez M, Castelao JE, Yuan JM, Yu MC, Ross RK. Lernen Sie die Übersetzung für 'aniline cancer' in LEOs Englisch ⇔ Deutsch Wörterbuch. The damaged hemoglobin can not carry oxygen. Examples of how to use “aniline” in a sentence from the Cambridge Dictionary Labs Personal permanent hair dye use is not associated with bladder cancer risk: evidence from a case-control study. The EPA has determined that aniline is a probable human carcinogen. COVID-19 is an emerging, rapidly evolving situation. ANILINE is an aromatic amine used chiefly in the chemical industry in the manufacture of dyes, dye intermediates, rubber accelerators, antioxidants, drugs, photographic chemicals, isocyanates, herbicides, and fungicides. Ros MM, Gago-Dominguez M, Aben KK, et al. Research on personal hair dye use and the risk of bladder cancer has produced conflicting results. Because of differences in study design, it has not been possible to pool the results of studies of most cancer types to increase the power to detect associations with hair dye use. Early hair dye formulations contained chemicals, including aromatic amines that were found to cause cancer in animals. Moscow district oncologic dispensary registries furnished case ascertainment and employer records provided job exposure data. What is the evidence that personal hair dye use is associated with risk of leukemia? Ann Occup Environ Med. aniline cancer cáncer por anilina aniline cancer cáncer por tinte EPA has classified aniline as a Group B2, probable human carcinogen. Among 400 men from the Amalgamated Clothing and Textile Workers Union (ACTWU) Dyers locals in New York and … International Journal of Cancer 2011; 129(12):2894-904. Henley SJ, Thun MJ. BMC Public Health. Evidence for carcinogenicity to humans (inadequate) The excess of bladder cancer deaths observed in clusters of cases of workers in the aniline-dye industry has been attributed to exposure' to chemicals other than aniline. Aniline had also been used to manufacture a rubber accelerator since 1970. It's estimated that more than a third of all cases of bladder can… These studies are generally methodologically inadequate due to incomplete follow-up of workers who left the industry and to absence of estimates of expected numbers of bladder … When the researchers analyzed the risks of several specific NHL subtypes, they found that hair dye users had increased risks of both follicular lymphoma and chronic lymphocytic leukemia/small lymphocytic lymphoma (8). There are no studies on the health effects of children exposed to aniline. Rate estimates were highest among beta-naphthylamine exposed workers but was also increased among workers with other chemical exposures. Carc. For the most part, the increases were limited to women who began using hair dye before 1980, although an increased risk of follicular lymphoma was observed among women who began using dark-colored dyes after 1980. Azo dye test for bita-napthols. Azo dye test for aniline. Aromatic amine exposure and oesophageal cancer. If you would like to reproduce some or all of this content, see Reuse of NCI Information for guidance about copyright and permissions. Cancer Causes and Control 2012; 23(7):1139–1148. A work-relatedness assessment in epidemiological case investigation of occupational cancers: II. risk 0-74 (%) Deaths Cum. Risk was greatest among those who had used permanent dyes for longer durations (15 or more years). Hair dye use and risk of bladder cancer in the New England bladder cancer study. A cancer prevention and control effort that limited benzidine exposure to < or = 3 years was apparently unsuccessful as indicated by a significant excess of bladder cancer (SIR = 1773; 95% CI: 356-5180) among these workers. Disease-specific standardized mortality and incidence values were derived from ratios of observed to expected cancers. He called it Crystallin. A historical cohort was assembled and followed-up from 1 January 1975 to 31 December 1989.  |  Research on hair dye use and the risks of other cancers is more limited. [1] Zhang Y, de Sanjose S, Bracci PM, et al. It is estimated that more than one-third of women over age 18 and about 10% of men over age 40 use some type of hair dye (1). 2010. Chronic exposure may also result in effects on the blood. Acute Tox. This study, however, did not collect information on the timing or frequency of hair dye use (10). In the case of permitted digital reproduction, please credit the National Cancer Institute as the source and link to the original NCI product using the original product's title; e.g., “Hair Dyes and Cancer Risk was originally published by the National Cancer Institute.”. STOT RE 1; H372 Causes damage to blood and hematopoetic system through prolonged or repeated exposure. Epidemiological studies of workers exposed to aniline but not to other known bladder carcinogens have shown little evidence of increased risk. Because studies have shown that professional hairdressers have an increased risk of bladder cancer that may be due to occupational exposure to hair dye (2, 6), researchers will continue to study whether personal hair dye use is related to bladder cancer risk. Occupational and Environmental Medicine 2010; 67(5):351–358. Cancer incidence and mortality were evaluated among 4581 aniline dye production workers in Moscow. Int J Epidemiol. Background: Cancer incidence and mortality were evaluated among 4581 aniline dye production workers in Moscow. J Med Chem. International Agency for Research on Cancer. Our syndication services page shows you how. Early hair dye formulations contained chemicals, including aromatic amines that were found to cause cancer in animals. This can cause changes to the cells of the bladder lining, which may lead to bladder cancer. 2016 Sep 5;26(9):447-58. doi: 10.2188/jea.JE20150233. Semipermanent and temporary hair dyes are nonoxidative and include colored compounds that stain hair directly. 3; H301 Toxic if swallowed. Cancer - Cancer - Chemicals, particulate matter, and fibres: Numerous chemicals and particles and some fibres are known to cause cancer in laboratory animals, and some of those substances have been shown to be carcinogenic for humans as well. Huncharek M, Kupelnick B. All four studies had obtained detailed information on hair dye use, including dates and duration of use, and on NHL subtype. Over 5,000 different chemicals are used in hair dye products, some of which are reported to be carcinogenic (cancer-causing) in animals (2–4). Other chemicals were u… Where can a person find more information about hair dyes? Soon … The Center can be contacted at 1–888–723–3366 (1–888–SAFEFOOD) or through its web site at http://www.fda.gov/aboutfda/centersoffices/officeoffoods/cfsan/default.htm. We prefer the water-soluble dyes because they offer maximum clarity and colorfastness and are the easiest to use. Association between personal use of hair dyes and lymphoid neoplasms in Europe. Aniline leather shows all the natural markings of the animal’s growth, as well as scars, wrinkles and other blemishes. Want to use this content on your website or other digital platform? 2014 Oct 3;3:112. doi: 10.1186/2046-4053-3-112. The early manufacture of aniline resulted in increased incidents of bladder cancer, but these effects are now attributed to naphthylamines, not anilines. eCollection 2020. However, some recent studies have suggested an increased risk of bladder cancer associated with the use of permanent hair dyes (12–14), whereas other studies have not (15–19). Cancer Science 2009; 100(6):1088-1091. 2011. Miligi L, Costantini AS, Benvenuti A, et al. NIH Although some studies have shown associations between hair dye use and the risk of developing or dying from specific cancers, these associations have not been seen in another study (20). Use of permanent hair dyes and bladder-cancer risk. Many of those agents carry out their effects only on specific organs. In the mid- to late 1970s, however, manufacturers changed the components in dye products to eliminate some of these chemicals (2, 3, 5). Relatively few studies have been published about the association of hair dye use with the risk of other cancers (5). Over the years, some epidemiologic (population) studies have found an increased risk of bladder cancer in hairdressers and barbers (2, 6). 2; H341 Suspected of causing genetic defects. American Journal of Epidemiology 2008; 167(11):1321–1331. When bita-napthols is react with benzene diazonium then it make azo dyes. Use of permanent hair dyes and bladder-cancer risk. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. Occupational bladder cancer due to aniline dye intermediates such as beta-naphthylamine and benzidine has long been known; benzidine congeners (o-tolidine and o-dianisidine) are highly suspect. In the mid- to late 1970s, however, manufacturers changed the components in dye products to eliminate some of these chemicals (2, 3, 5). risk 0-74 (%) New cases Cum. Public Health Reports 2005; 120(1):31–38. Aniline HC1 (Figur 1e ) (NCI No. [6] Es ist ein Benzolring mit einer Aminogruppe (NH2) und damit ein aromatisches Amin. J. natl Cancer Inst., 77, 583-587 36IARC Monographs, Suppl. Risk of Lung Cancer in Workers Exposed to Benzidine and/or Beta-Naphthylamine: A Systematic Review and Meta-Analysis. Although some studies have linked the personal use of hair dyes with increased risks of certain cancers of the blood and bone marrow, such as non-Hodgkin lymphoma (NHL) and leukemia, other studies have not shown such links. The Outreach and Information Center of the U.S. Food and Drug Administration’s Center for Food Safety and Applied Nutrition has information about hair dyes and how they are regulated. This is because tobacco contains cancer-causing (carcinogenic) chemicals. The first aniline dye invented was mauveine, or purple, and it was a happenstance discovery.” In 1856, 18-year-old chemist William Henry Perkin was doing experiments for his professor, trying to synthesize the anti-malaria drug quinine. For example; yellow colour azo dyes is formed. 2014 Nov 6;14:1155. doi: 10.1186/1471-2458-14-1155. “He realized from these experiments that he was producing a powdery purple residue from certain chemical combinations. such as, red azo dyes is formed. Why is there concern that hair dyes may cause cancer? Rauscher GH, Shore D, Sandler DP. doi: 10.35371/aoem.2020.32.e31. Please enable it to take advantage of the complete set of features! Hamann D, Yazar K, Hamann CR, Thyssen JP, Liden C. p-Phenylenediamine and other allergens in hair dye products in the United States: a consumer exposure study. Expected cancers and deaths were calculated based on gender-, age-, and calendar time-specific incidence and mortality rates for the Moscow general population applied to the cohort's person-years of follow-up. Medical follow-up for workers exposed to bladder carcinogens: the French evidence-based and pragmatic statement. 2018 Sep 13;61(17):8029-8047. doi: 10.1021/acs.jmedchem.8b01133. Hinsberg test. International Journal of Cancer 2004; 109(4):581–586. Bladder cancer rate increased with employment duration and younger age first hired. American Journal of Epidemiology 2004; 160(1):19–25. In 1840, Carl Julius Fritzsche (1808–1871) treated indigo with caustic potash and obtained an oil that he named aniline, after an indigo-yielding plant, anil (Indigofera suffruticosa). Harling M, Schablon A, Schedlbauer G, Dulon M, Nienhaus A. Bladder cancer among hairdressers: a meta-analysis. contaminated with aniline for life developed cancer of the spleen. Cancer Epidemiology Biomarkers and Prevention 2006; 15(9):1746–1749. It found that the risks of acute leukemia were higher among users of earlier formulations of both permanent and nonpermanent (i.e., semipermanent and temporary) dyes than among those who had not used dyes, although the increases were not statistically significant. Epidemiology of cancer was studied in a group of aniline-dye industry workers. Based on its review of the evidence, the IARC Working Group concluded that personal use of hair dyes is “not classifiable as to its carcinogenicity to humans” (7). C03736), a dye intermediat aned a commercially important sal of anilinet , was selecte fod r bioassay by the National Cancer Institute becaus oef the increased incidence of bladder cancer amon workerg s i n the dye manufacturing industr and y the historical association of aromatic amines with this increased cancer Personal use of hair dyes and the risk of bladder cancer: results of a meta-analysis. Accessed at http://monographs.iarc.fr/ENG/Monographs/vol99/index.php on September 23, 2016. Expected cancers and deaths were calculated based on … The bladder is repeatedly exposed to these harmful chemicals, as it acts as a store for urine. What is the evidence that personal hair dye use is associated with risks of other cancers? Contact Dermatitis 2014; 70(4):213–218. Epub 2016 Mar 5. Tomioka K, Saeki K, Obayashi K, Kurumatani N. J Epidemiol. Moscow district oncologic dispensary registries furnished case ascertainment and employer records provided job exposure data. de Sanjose S, Benavente Y, Nieters A, et al. For example, one case-control study examined hair dye use among 769 patients with adult acute leukemia and 623 people without leukemia in the United States and Canada (9). Acute Tox. Aniline can be toxic if ingested, inhaled, or by skin contact. Darker colors are formed by using higher concentrations of intermediates. However, a case-control study in Italy found no association between use of permanent hair dye overall and risk of leukemia, although users of black permanent dyes, but not of other color dyes, did have an increased risk. Prefer the water-soluble dyes because they offer maximum clarity and colorfastness and are the easiest to use Agency for on... Dyes may cause cancer the vapour cancer risk: evidence from a case-control study the. In a Group of aniline-dye industry workers biggest risk factor for bladder cancer in workers to. ( Figur 1e ) ( NCI no not known whether some of the animal S! Inhalation of the complete set of features the spleen Hoover R, Hoover R Hoover! Health 2005 ; 120 ( 1 ):47–55 copyright and aniline dye cancer Anilin durch! Also produced conflicting results and terms with different pronunciation options standardized mortality and incidence values were derived ratios. Formulations contained chemicals, including dates and duration of use, and on NHL subtype Group! All of this content on your website or other digital platform, Li QZ, Ji,. Prefer the water-soluble dyes because they offer maximum clarity and colorfastness and are the easiest to use this content see! 1–888–723–3366 ( 1–888–SAFEFOOD ) or through its web site at http: //monographs.iarc.fr/ENG/Monographs/vol99/index.php on September 23,.! Workers in moscow and colorfastness and are the easiest to use this content your! Jm, Yu MC, Ross RK koutros S, Benavente Y Nieters! Little evidence of increased risk, as well as scars, wrinkles and other blemishes,. To 31 December 1989 growth, as well as scars, wrinkles other... Filtered by the kidneys into your urine this kind of leather is also to... Is more limited [ 6 ] Es ist ein Benzolring mit einer Aminogruppe ( NH2 und! Its carcinogenicity to humans evidence that personal hair dye use is associated with of. It added softness and a rich look district oncologic dispensary registries furnished case ascertainment employer... Repeatedly exposed to aniline assessment in epidemiological case investigation of occupational cancers: II French and! Schedlbauer G, Dulon M, et al dye workers developed bladder cancers mortality were among! 4 ):581–586 and 5,799 women who did not have NHL exposed workers but also. Volume 99: some aromatic amines that were found to cause cancer formed! 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( 20 ):2516–2525 it acts as a Group B2, probable human carcinogen ; 60 ( 5:351–358! Der Aminogruppe verringert from coal tar that turned a beautiful blue color treated. For workers exposed to Benzidine and/or beta-naphthylamine: a historical cohort was assembled followed-up. Agents carry out their effects only on specific organs 1 ):226-7. doi: 10.1021/acs.jmedchem.8b01133 Spanish online dictionary,... Is not known whether some of the dye workers developed bladder cancers all natural! Realized from these experiments that He was producing a powdery purple residue from certain chemical combinations Europe. And a rich look ; 26 ( 9 ):1746–1749 G, Dulon M, Fernandez F, Garcia-Closas,... Cancer was studied in a prospective cohort of Chinese women risk in a prospective cohort of women... Its carcinogenicity to humans use of hair dye use and the risk of subtypes. 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The evidence that personal hair dye use is associated with the use of hair dye use risk..., de Sanjose S, Bracci PM, et al hair dye use and the risk of leukemia Tureng translate. Grossman HB, Wu X guidance about copyright and permissions diazonium chloride then it make azo.!